Maternotoxicity of Leachate from CETP Pali, When Administered to Swiss Albino Mice during Various Stages of Reproductive Cycle

The present study deals with the maternotoxicity of leachate from Combined Effluent Treatment Plant CETP Pali, Rajasthan, India when administered to Swiss albino mice during various stages of reproductive cycle. An attempt has been made to study the maternotoxic effect of sludge leachate obtained from CETP, Pali which receives effluent exclusively from textile and dyeing industries located at Pali. Sludge leachate was diluted with water according to dose concentration of 1/100 and 1/10 respectively and then administered to Swiss albino mice during three different stages of gestation like prior to and throughout gestation , organogenetic and growth phase along with control group receiving simple tap water in order to access the most vulnerable stage. Research finding reveals that the treated sludge leachate from CETP, Pali at the tested dose levels produced maternal toxicity to certain extent. Maternal toxicity due to sludge leachate was evident by significant reduction in body weight gain, substantial loss of body fur and restlessness. The toxic symptoms in mothers were muscular tremors, ataxia, convulsions, hyper salivation, lacrimation and restlessness